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The Science Behind Meal Sequencing: What Really Works

The Science Behind Meal Sequencing: What Really Works

October 3, 2025
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Why Food Order Matters


Different nutrients interact with the digestive system in different ways:


1. Fibre slows carbohydrate absorption


  • How it works: Soluble fibre (from oats, beans, apples, flax, and vegetables) forms a gel in the gut that slows how quickly food leaves the stomach and how fast sugar is absorbed.

  • Effect: Carbs eaten after fibre cause a slower, smaller glucose rise — and less insulin is needed.

  • Example: A salad or vegetable soup before pasta reduces the size of the blood sugar spike compared to pasta alone.


2. Protein boosts incretin hormones (GLP-1, GIP)


  • How it works: Protein triggers gut hormones that “prime” the pancreas to release insulin sooner and more effectively. GLP-1 also slows digestion and increases satiety.

  • Effect: Blood sugar rises more smoothly, insulin works better, and you feel fuller.

  • Example: Chicken, fish, or even a whey protein shake before rice dampens the glucose spike.


💡 Curious to learn more about these gut hormones? Check out my post on Appetite-Regulating Hormones.


3. Fat activates the “ileal brake”


  • How it works: When fat reaches the lower gut, it sends a feedback signal to slow digestion.

  • Effect: Carbs eaten with or after fat are absorbed more slowly, blunting the spike. Fat also promotes satiety through gut hormones like GLP-1.

  • Example: Olive oil on vegetables or a handful of nuts before bread slows carb digestion.


What Studies Actually Show


  • In people with diabetes or prediabetes, eating vegetables/protein/fat before carbs can reduce glucose spikes by 20–40%.

  • In short-term studies, sequencing reliably blunts glucose rises after meals.

  • Satiety benefits are seen in some cases, possibly reducing overall calorie intake.


But here’s the catch:


  • Most research has been done in people with diabetes, not healthy individuals.

  • In healthy people, glucose spikes naturally return to baseline within 2–3 hours.

  • We don’t yet know if reducing these spikes changes long-term outcomes like weight loss, diabetes prevention, or heart health.


What We Still Don’t Know


  • Long-term benefits in healthy people remain unproven.

  • Glucose spikes in non-diabetic people are usually normal, not harmful.

  • Over-focusing on sequencing can lead to unnecessary anxiety around food.


Practical Takeaway


If you’d like to try sequencing, keep it simple:


  1. Start with vegetables

  2. Add protein and healthy fats

  3. Save carbs for last


It’s an easy, no-cost tweak with proven short-term benefits — but it’s not a magic bullet. The real foundations of health are still balanced nutrition, portion control, and regular movement.



Final Thoughts


Meal sequencing is a fascinating tool: it clearly changes how the body processes carbs in the moment. But the long-term health impact isn’t yet clear, especially for people without blood sugar issues.

Consider it a bonus strategy — one that works best alongside healthy eating habits, not instead of them.


For personalised nutrition advice, book a Consultation — together we can create a plan tailored to your health goals.


Reference List:


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  • Jakubowicz, D et al. (2014) 'Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial', Diabetologia, vol. 57, no. 9, pp. 1807-1811. Available at: https://link.springer.com/article/10.1007/s00125-014-3305-x

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  • Lu, JC et al. (2019) 'Postprandial glucose, insulin and incretin responses differ by test meal macronutrient ingestion sequence (PATTERN study)', Clinical Nutrition, vol. 38, no. 6, pp. 2617-2623. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0261561419301542

  • Ma, J et al. (2009) 'Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes', Diabetes Care, vol. 32, no. 9, pp. 1600-1602. Available at: https://diabetesjournals.org/care/article/32/9/1600/28666/Effects-of-a-Protein-Preload-on-Gastric-Emptying

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